Radboud University Medical Center

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RADBOUD CENTER

Laboratory

Research within the Department aims at a better understanding of our immune system using molecular-, cell biological- and immunological- techniques and is centred around antigen presenting dendritic cells which play an important role in regulating the immune response. An important activity of the Department is the translation of basic research into clinical application. In particular, research focusses on the development of novel dendritic cell based vaccines to treat cancer patients.

Staff enrolled in the project

  • Prof. I. Jolanda M. de Vries
    Prof. I. Jolanda M. de VriesProfessor translational immunology

    +31-24-3617600

    Jolanda de Vries was one of the pioneers to translate dendritic cell biology into potential clinical applications. The first clinical phase I/II studies in which patients were vaccinated with DCs loaded with tumor-specific peptides were initiated in 1997. She also developed a novel immuno-monitoring assay that is highly predictive for extended survival after vaccination with DCs. Her primary scientific interest continues along the line of DC-immunotherapy and in particular the migration and imaging of DC. New opportunities for other cell-types (e.g. subsets of DCs) are now being developed. She recently completed the first plasmacytoid DC vaccination trial.

  • Prof. W. Gerritsen
    Prof. W. GerritsenMedical oncology, translational oncology and immunotherapy

    +31-24-3610354

    He has extensive expertise in translational research with a special interest in tumor-immunology and prostate cancer. Following his medical training at the University of Nijmegen, Prof. Gerritsen achieved his PhD in 1989 on bone marrow transplantation at the Medical School of the Erasmus University of Rotterdam, where after he worked in different positions at Memorial Sloan Kettering Cancer Center in New York, the University Hospital Utrecht, The Netherlands Cancer Institute / Antoni van Leeuwenhoek Hospital and the VU Medical Center.