CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (CNIC)
Laboratory/department/unit description where is going to be performed the scientific work
Immunobiology of inflammation lab
Our main interest is how dendritic cells (DC) and macrophages modulate immunity and inflammation. We are interested in the analysis of DC subsets, their specific functions and plasticity. We have found that Batf3-dependent DCs are crucial for generation of Th1 immunity through the production of IL-12 (Martínez-López et al. 2015. Eur. J. Immunol.). We analyzed the Th1-immunity model of infection by the eukaryote parasite Leishmania major, which induces tissue damage and it is also a eukaryote that mimics many danger signals from tissue. We have also found that Batf3-dependent DCs do not play a major role in the development of atherosclerosis. In contrast, in collaboration with the group of Dr. Ignacio Melero (CIMA and Clínica Universitaria de Navarra, Pamplona) we have found that cross-presenting DCs are crucial for the generation of a basal immune response that can be rescued by immunostimulatory antibodies for cancer immunotherapy (Sánchez-Paulete et al. 2015, Cancer Discovery).
We have also analyzed the modulation of signals through C-type lectin receptors and have found that SHIP-1 associates to the intracellular hemITAM motif in Dectin-1 and selectively modulates its ability to induce reactive oxygen species in DC (Blanco-Menéndez et al. 2015. J. Immunol.). In addition, we are working on DNGR-1 as a model C-type lectin that detects tissue damage during infection and we have determined an impact in the CD8+ T cell memory response. We are also analyzing the effects of sensing non-self and damaged-self in the metabolism of myeloid cells. We believe that this research has potential for the development of new vaccines and immunotherapy strategies.